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Systemic pharmacology Irrespective of the primaryaction of the drug, its effects on major organ systemssuch as nervous, cardiovascular, respiratory, renal, g.i.tare worked out. Eliyahu D, Raz A, Gruss P, Givol D, Oren M (1984) Participation of p53 cellular tumourantigen in transformation of normal embryonic cells. 2004 ;CDC 2004; Chastre and Fagon 2002 ; Collardet al. The vital centres located in themedulla are paralysed the last as the depth ofanaesthesia increases.

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